Pothos is a tropical plant but, unlike many true tropicals, it doesn’t resent a little exposure to cold drafts, dry air or even drought. Because it grows in the forest under story it is also adapted to very low light levels. These characteristics of toughness make it an ideal houseplant. About the only thing that will kill pothos is to let it sit in water. Any excess water that accumulates around the base of the pot should be drained away after each watering. It will occasionally get mealy bugs or spider mites, but these insect pests are usually not fatal.